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KMID : 1098420150230010037
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Korean Journal of Medicinal Crop Science
2015 Volume.23 No. 1 p.37 ~ p.42
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Effect of Anti-Skin Wrinkle and Antioxidant of Agastache rugosa Kentz through Fermentation Process of the lactic acid
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Kim Nam-Young
Park Dae-Su
Lee Hyeon-Yong
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Abstract
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This study was to investigate anti-skin wrinkle effect of Agastache rugosa Kentz extracts by extraction processes. In the comparison of the effect of the solvent extraction, the extracts by 70% ethanol (EE) showed better biological activities that those by hot water. Therefore, further fermented Agastache rugosa was applied to 70% ethanol extraction process (FEE). FEE showed higher DPPH scavenging activity of 62.98% than EE’s 62.71% at 1.0 ㎎/㎖, but there was no significant. Elastase inhibition was measured 23.0% from FEE at 1.0 ㎎/㎖. Cytotoxicity showed the highest 16.26% from FEE, this value is safe in the cell experiment. Collagen production showed 113.1 ng/㎖ from FEE, on the other hand EE was measured 77.4 ng/㎖ in adding 1.0 ㎎/㎖. MMP-1 production was observed 1398 pg/㎖ from FEE and EE was measured 1632 pg/㎖. These results were found the highest antioxidant and anti-wrinkle effect. As a result, it was also confirmed that anti-skin wrinkle activities of the Agastache rugosa Kentz extract was correlated with anti-oxidant activities.
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KEYWORD
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Anti-Skin Wrinkle Effect, Antioxidant, Agastache rugosa Kuntz, Collagen, Lactic Acid, MMP-1
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